Turmeric for IBD
Question:
it sounds interesting to say the least. have you found anyone who has tried it yet? if i hadn’t already identified it as a spice that bothers me, i think i wouldn’t see any harm in trying it. that and the digestive enzyme thing. like i said before, maybe i’m just messed up. nadia. – Hide quoted text — Show quoted text – > Taking turmeric with bromelain is supposed to help, but that is also a > digestive enzyme (derived from pineapple). > Here’s some extensive, referenced, scientific details on turmeric / > curcumin: > TURMERIC > Latin Name: Curcuma longa Linn. (Zingiberaceae) > English Name: Turmeric > Sanskrit Names: Haridra, Rajani, Nisha > Hindi Names: Haldi, Halada > Preparation: The rhizomes are dug in autumn or winter. After the bark and > fibrous roots have been removed, the rhizomes are cleaned, boiled, dried in > the sun and cut into slices. > Turmeric has been used in Indian systems of medicine for thousands of years. > It is listed in an Assyrian herbal dating from about 600 BC and is mentioned > by Dioscorides. > Turmeric supports the body’s innate ability to regulate inflammation at the > cellular level where it originates. It inhibits both platelet aggregation > and neutrophil response to various stimuli. The main active ingredient > curcumin, a diferuloyl methane (chemical formula C21H20O6, > 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) protects > against cancer and is well researched for it’s ability to prevent genetic > mutations. Turmeric is safe even at high doses, with no reported side > effects. The main natural active curcuminoids active are diferuloylmethane, > feruloyl-p-hydroxycinnamoylmethane and bis-(p-hydroxycinnamoyl) methane. > In Ayurvedic medicine (the traditional medicine of India) many different > species similar to turmeric are used. It was prescribed for treatment of > many conditions, including poor vision, rheumatic pains, coughs, and to > increase milk production. Native peoples of the Pacific sprinkled the dust > on their shoulders during ceremonial dances, as well as using it for > numerous medical problems ranging from constipation to skin diseases. It was > used for numerous intestinal infections and ailments in Southeast Asia. > Curcumin reduces histamine levels and possibly increases production of > natural cortisone by the adrenal glands. It also protects the liver from > toxic compounds and has been shown to reduce platelets from clumping > together, which in turn improves circulation and helps protect against > atherosclerosis. > Many people take 400 mg of curcumin three times per day in capsules or > tablets. Tincture can be used in the amount of 0.5-1.5 ml, three times per > day. Turmeric as a spice can also be incorporated into the diet as a way to > promote health. > Curcumin has a similar action to that of aspirin and aspirin-like > anti-inflammatory agents. There is, however, an important advantage for > curcumin over aspirin, since curcumin, unlike aspirin, selectively inhibits > synthesis of inflammatory prostaglandins but does not affect the synthesis > of prostacyclin. Prostacyclin is an important factor in preventing vascular > thrombosis, and any drug that affects its synthesis, especially when used in > large doses, may increase the risk of this dangerous condition. Curcumin may > therefore be preferable for patients who are prone to vascular thrombosis > and require anti-inflammatory and/or antiarthritic therapy. > Studies have found faster wound closure of punch wounds in curcumin-treated > animals in comparison with untreated controls. > Studies have shown that curcumin inhibits cytokine-mediated NF-[kappa]B > activation in some cell types. NF-[kappa]B plays a critical role in the > transcriptional regulation of proinflammatory gene expression in various > cells. > Although curcumin has such remarkable pharmacology, its absorption rate is > the intestinal tract is poor. However when taken with bromelain, the > absorption rate is highly increased. Bromelain, extracted from pineapple is > a protein- digesting enzyme that functions as a digestive aid and is also > anti-inflammatory. > The pleiotropic cytokine tumor necrosis factor-alpha (TNF) induces the > production of interleukin-1 beta (IL-1), and, together, they play > significant roles in many acute and chronic inflammatory diseases. Curcumin > has been shown to inhibit lipopolysaccharide (LPS)-induced production of TNF > and IL-1 by a human monocytic macrophage cell line, Mono Mac 6. > Turmeric has been shown to increase the gastric wall mucus in laboratory > rats. > Curcuminoids inhibit enzymes that participate in the synthesis of > inflammatory substances in the body. The natural anti-inflammatory activity > of curcuminoids is comparable in strength to steroidal drugs, and such > non-steroidal anti-inflammatory drugs as indomethacin and phenylbutazone. > Diets supplemented with curcuminoids protect the integrity of biomolecules > in the body. Preventing the deterioration of food, and keeping nutrients in > tissues from degenerating, appear to be closely related. For example, the > properties in turmeric which prevent meat from becoming rancid help to > provide edible animal protein that contains less oxidized fat or free > radicals. When this type of food is ingested, it supplies clean nutrients > rather than free radical-damaged nutrients. > The same attributes of turmeric that preserve the freshness of food may also > protect living tissue from degenerative disease. Feeding curcuminoids to > laboratory animals resulted in elevated levels of the enzyme glutathione > S-transferase, an important index of the efficiency of detoxification. > For centuries, turmeric has been used as a food additive, a medicinal agent > and a dye for cosmetics and fabrics without manifesting side effects. This > record of safety has been one of the deciding factors that allowed the Food > and Agricultural Organization and the W.H.O. committee on food additives to > approve curcuminoids as natural food coloring agents. > People who should avoid taking turmeric: > – people with childbearing / fertility problems; > – people with blood-clotting problems; > – people on anti-coagulant medication; > – people with symptoms of gallstones. > References: > Anto RJ, George J, Dinesh Babu KV, Rajasekharan KN, Kuttan R (1996). > "Antimutagenic and anticarcinogenic activity of natural and synthetic > curcuminoids," Mutation Research – Genetic Toxicology (Netherlands) > 370/2:127-131. > Arora RB, Basu N, Kapoor V, Jain AP. Anti-inflammatory studies on Curcuma > longa (turmeric). Ind J Med Res 1971;59:1289-95. > Chandra, D., and Gupta, S.S. (1972). "Anti-inflammatory and Anti-arthritic > Activity of Volatile Oil of C. Longa," Ind. J. Med. Res. 60:138. > Deodhar, S.D., et al. (1980). "Preliminary Studies on Anti-Rheumatic > Activity of Curcumin," Ind. J. Med. Res. 71:632. > Hastak K, Lubri N, Jakhi S, et al. (1997) "Effect of turmeric oil and > turmeric oleoresin on cytogenic damage in patients suffering from oral > submucous fibrosis," Cancer Letters 116:265-269. > Jain, J.P., et al. (1979). "Clinical Trials of Haridra in Cases of Tamak > Swasa and Kasa," J. Res. Indian. Med. Yoga and Homeo. 14:110. > Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, and Sartor RB > (1999). "Curcumin blocks cytokine-mediated NF-[kappa]B activation and > proinflammatory gene expression by inhibiting inhibitory Factor I-[kappa]B > Kinase activity", Journal of Immunology 163: 3474-3483. > Kiso Y, Suzuki Y, Watanbe N, et al. Antihepatotoxic principles of Curcuma > longa rhizomes. Planta Med 1983;49:185-7. > Kuo M-L, Huang T-S, Lin J-K (1996), "Curcumin, an antioxidant and anti-tumor > promoter, induces apoptosis in human leukemia cells," Biochimica et > Biophysica Acta-Molecular Basis of Disease (Netherlands),1317/2:9-100. > Majeed M, Badmaev V, "Turmeric and the Healing Curcuminoids" Keats > Publishing, Inc.. > Sidhu GS, Singh AK, Thaloor D, et al. (1998). "Enhancement of wound healing > by curcumin in animals," Wound Repair Regen. 6:167-177. > Sreejayan N, Rao MNA. Free radical scavenging activity of curcuminoids. > Arzneim Forsch Drug Res 1996;46:169-71. > Srimal, R.C., and Dhawan, B.N. (1985). "Pharmacological and Clinical Studies > on Curcuma Longa," Hamdard Nat’l. Found. Monograph, New Delhi, India, > Section 3B(ii). > Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Anti-thrombotic effect of > curcumin. Thromb Res 1985;40:413-17. > Srivastava, V., et al. (1986). "Effect of Curcumin on Platelet Aggregation > and Vascular Prostacyclin Synthesis," Arzneim. Forsch > Sreejayan N, Rao MNA (1997). "Nitric oxide scavenging by curcuminoids," > Journal of Pharmacy and Pharmacology (UK) , 49/1:105-107. > "Inhibition of tumor necrosis factor by curcumin, a phytochemical" > Biochem-Pharmacol. 1995 May 26; 29(11):1551-6. > "Evaluation of turmeric (curcuma longa) for gastric and duodenal antiulcer > activity in rats," J-Ethnopharmacol. 1990 Apr; 29(1):25-34.
Response:
i seem to be upside down and backwards or something but i know that tumeric is one of the spices that upsets my stomach. (i also get diarrhea from those digestive enzymes, remember?) nadia. – Hide quoted text — Show quoted text – > There have been reports that turmeric is a potent natural anti-inflammatory, > particularly due to its high levels of a natural chemical called curcumin. > My questions are as follows: > 1) Does anyone know where to obtain pure curcumin? > 2) Has anyone tried pure curcumin? > 3) To obtain the anti-inflammatory effects from turmeric by adding turmeric > to your food (or dissolving the yellow powder in water and gulping it down – > yuk!), requires 4-8 teaspoonfuls a day! Has anyone tried this? Success? > In a recent book I’ve obtained called Beyond Cortisone, the medical author > proposes that turmeric / curcumin may even be able to replace the dreadful > (but effective) prednisone. > Bryan
Response:
Taking turmeric with bromelain is supposed to help, but that is also a digestive enzyme (derived from pineapple). Here’s some extensive, referenced, scientific details on turmeric / curcumin: TURMERIC Latin Name: Curcuma longa Linn. (Zingiberaceae) English Name: Turmeric Sanskrit Names: Haridra, Rajani, Nisha Hindi Names: Haldi, Halada Preparation: The rhizomes are dug in autumn or winter. After the bark and fibrous roots have been removed, the rhizomes are cleaned, boiled, dried in the sun and cut into slices. Turmeric has been used in Indian systems of medicine for thousands of years. It is listed in an Assyrian herbal dating from about 600 BC and is mentioned by Dioscorides. Turmeric supports the body’s innate ability to regulate inflammation at the cellular level where it originates. It inhibits both platelet aggregation and neutrophil response to various stimuli. The main active ingredient curcumin, a diferuloyl methane (chemical formula C21H20O6, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) protects against cancer and is well researched for it’s ability to prevent genetic mutations. Turmeric is safe even at high doses, with no reported side effects. The main natural active curcuminoids active are diferuloylmethane, feruloyl-p-hydroxycinnamoylmethane and bis-(p-hydroxycinnamoyl) methane. In Ayurvedic medicine (the traditional medicine of India) many different species similar to turmeric are used. It was prescribed for treatment of many conditions, including poor vision, rheumatic pains, coughs, and to increase milk production. Native peoples of the Pacific sprinkled the dust on their shoulders during ceremonial dances, as well as using it for numerous medical problems ranging from constipation to skin diseases. It was used for numerous intestinal infections and ailments in Southeast Asia. Curcumin reduces histamine levels and possibly increases production of natural cortisone by the adrenal glands. It also protects the liver from toxic compounds and has been shown to reduce platelets from clumping together, which in turn improves circulation and helps protect against atherosclerosis. Many people take 400 mg of curcumin three times per day in capsules or tablets. Tincture can be used in the amount of 0.5-1.5 ml, three times per day. Turmeric as a spice can also be incorporated into the diet as a way to promote health. Curcumin has a similar action to that of aspirin and aspirin-like anti-inflammatory agents. There is, however, an important advantage for curcumin over aspirin, since curcumin, unlike aspirin, selectively inhibits synthesis of inflammatory prostaglandins but does not affect the synthesis of prostacyclin. Prostacyclin is an important factor in preventing vascular thrombosis, and any drug that affects its synthesis, especially when used in large doses, may increase the risk of this dangerous condition. Curcumin may therefore be preferable for patients who are prone to vascular thrombosis and require anti-inflammatory and/or antiarthritic therapy. Studies have found faster wound closure of punch wounds in curcumin-treated animals in comparison with untreated controls. Studies have shown that curcumin inhibits cytokine-mediated NF-[kappa]B activation in some cell types. NF-[kappa]B plays a critical role in the transcriptional regulation of proinflammatory gene expression in various cells. Although curcumin has such remarkable pharmacology, its absorption rate is the intestinal tract is poor. However when taken with bromelain, the absorption rate is highly increased. Bromelain, extracted from pineapple is a protein- digesting enzyme that functions as a digestive aid and is also anti-inflammatory. The pleiotropic cytokine tumor necrosis factor-alpha (TNF) induces the production of interleukin-1 beta (IL-1), and, together, they play significant roles in many acute and chronic inflammatory diseases. Curcumin has been shown to inhibit lipopolysaccharide (LPS)-induced production of TNF and IL-1 by a human monocytic macrophage cell line, Mono Mac 6. Turmeric has been shown to increase the gastric wall mucus in laboratory rats. Curcuminoids inhibit enzymes that participate in the synthesis of inflammatory substances in the body. The natural anti-inflammatory activity of curcuminoids is comparable in strength to steroidal drugs, and such non-steroidal anti-inflammatory drugs as indomethacin and phenylbutazone. Diets supplemented with curcuminoids protect the integrity of biomolecules in the body. Preventing the deterioration of food, and keeping nutrients in tissues from degenerating, appear to be closely related. For example, the properties in turmeric which prevent meat from becoming rancid help to provide edible animal protein that contains less oxidized fat or free radicals. When this type of food is ingested, it supplies clean nutrients rather than free radical-damaged nutrients. The same attributes of turmeric that preserve the freshness of food may also protect living tissue from degenerative disease. Feeding curcuminoids to laboratory animals resulted in elevated levels of the enzyme glutathione S-transferase, an important index of the efficiency of detoxification. For centuries, turmeric has been used as a food additive, a medicinal agent and a dye for cosmetics and fabrics without manifesting side effects. This record of safety has been one of the deciding factors that allowed the Food and Agricultural Organization and the W.H.O. committee on food additives to approve curcuminoids as natural food coloring agents. People who should avoid taking turmeric: – people with childbearing / fertility problems; – people with blood-clotting problems; – people on anti-coagulant medication; – people with symptoms of gallstones. References: Anto RJ, George J, Dinesh Babu KV, Rajasekharan KN, Kuttan R (1996). "Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids," Mutation Research – Genetic Toxicology (Netherlands) 370/2:127-131. Arora RB, Basu N, Kapoor V, Jain AP. Anti-inflammatory studies on Curcuma longa (turmeric). Ind J Med Res 1971;59:1289-95. Chandra, D., and Gupta, S.S. (1972). "Anti-inflammatory and Anti-arthritic Activity of Volatile Oil of C. Longa," Ind. J. Med. Res. 60:138. Deodhar, S.D., et al. (1980). "Preliminary Studies on Anti-Rheumatic Activity of Curcumin," Ind. J. Med. Res. 71:632. Hastak K, Lubri N, Jakhi S, et al. (1997) "Effect of turmeric oil and turmeric oleoresin on cytogenic damage in patients suffering from oral submucous fibrosis," Cancer Letters 116:265-269. Jain, J.P., et al. (1979). "Clinical Trials of Haridra in Cases of Tamak Swasa and Kasa," J. Res. Indian. Med. Yoga and Homeo. 14:110. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, and Sartor RB (1999). "Curcumin blocks cytokine-mediated NF-[kappa]B activation and proinflammatory gene expression by inhibiting inhibitory Factor I-[kappa]B Kinase activity", Journal of Immunology 163: 3474-3483. Kiso Y, Suzuki Y, Watanbe N, et al. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med 1983;49:185-7. Kuo M-L, Huang T-S, Lin J-K (1996), "Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells," Biochimica et Biophysica Acta-Molecular Basis of Disease (Netherlands),1317/2:9-100. Majeed M, Badmaev V, "Turmeric and the Healing Curcuminoids" Keats Publishing, Inc.. Sidhu GS, Singh AK, Thaloor D, et al. (1998). "Enhancement of wound healing by curcumin in animals," Wound Repair Regen. 6:167-177. Sreejayan N, Rao MNA. Free radical scavenging activity of curcuminoids. Arzneim Forsch Drug Res 1996;46:169-71. Srimal, R.C., and Dhawan, B.N. (1985). "Pharmacological and Clinical Studies on Curcuma Longa," Hamdard Nat’l. Found. Monograph, New Delhi, India, Section 3B(ii). Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Anti-thrombotic effect of curcumin. Thromb Res 1985;40:413-17. Srivastava, V., et al. (1986). "Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis," Arzneim. Forsch Sreejayan N, Rao MNA (1997). "Nitric oxide scavenging by curcuminoids," Journal of Pharmacy and Pharmacology (UK) , 49/1:105-107. "Inhibition of tumor necrosis factor by curcumin, a phytochemical" Biochem-Pharmacol. 1995 May 26; 29(11):1551-6. "Evaluation of turmeric (curcuma longa) for gastric and duodenal antiulcer activity in rats," J-Ethnopharmacol. 1990 Apr; 29(1):25-34.
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